|
T9929 |
Ramucirumab
|
|
VEGFR
|
|
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. |
|
T10777 |
CG347B
|
|
HDAC
|
|
CG347B is a selective inhibitor of HDAC6. |
|
T21588 |
Olomoucine
|
|
ERK
,
CDK
|
|
Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an... |
|
T2325 |
Neratinib
|
HKI-272 |
EGFR
,
HER
|
|
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively. |
|
T13044 |
Mevociclib
|
SY-1365 |
CDK
|
|
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors. |
|
T9865 |
Almonertinib mesylate
|
|
EGFR
|
|
Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st... |
|
T8756 |
KRAS inhibitor-9
|
DUN09716 |
Apoptosis
,
Ras
|
|
KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ... |
|
T60076 |
Oritinib
|
SH-1028 |
EGFR
|
|
Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (d746-750), EGFR (d746-750/T790M), respectively. Oritinib can ... |
|
T5462 |
Almonertinib
|
HS-10296 |
EGFR
|
|
Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR. |
|
T5675 |
Almonertinib hydrochloride
|
HS-10296 hydrochloride |
EGFR
|
|
Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. |
|
T8656 |
CAY10404
|
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis
,
Akt
,
COX
|
|
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel... |
|
T1602 |
Valproic acid sodium salt
|
Sodium Valproate |
Mitophagy
,
Gamma-secretase
,
HIV Protease
,
GABA Receptor
,
HDAC
,
Autophagy
|
|
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha... |
|
T6474 |
Divalproex Sodium
|
Valproate semisodium,Epival |
HDAC
|
|
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme... |
|
T0373 |
Erlotinib
|
OSI-744,NSC 718781,CP358774,R1415 |
EGFR
,
Autophagy
|
|
Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer. |
|
T1758 |
ABT-751
|
E7010 |
Microtubule Associated
,
Autophagy
|
|
ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. |
|
T15390 |
Glufosfamide
|
D 19575,Glucosylifosfamide mustard |
Others
|
|
Glufosfamide is a novel oxazolophosphamide compound with anticancer activity for the study of advanced non-small cell lung cancer. |
|
T36404L |
PRLX-93936 HCL
|
PRLX-93936 hcl(903499-49-0 Free base) |
Ferroptosis
,
Reactive Oxygen Species
|
|
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin. |
|
T39275 |
Befotertinib
|
D-0316,Befotertinib |
EGFR
|
|
Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer. |
|
T30087 |
Antroquinonol
|
|
Reactive Oxygen Species
,
Nrf2
|
|
Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inhibits inflammation and sclerosis in mice with focal segment... |
|
T67934 |
MRT-2359
|
|
Others
|
|
MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits... |
|
T0373L |
Erlotinib hydrochloride
|
OSI-744,NSC 718781,Erlotinib HCl,CP-358774 |
EGFR
,
Autophagy
|
|
Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer. |
|
T9673 |
RET-IN-3
|
|
c-RET
|
|
RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer. |
|
T39764 |
KER047
|
ALK2-IN-4 |
ALK
|
|
KER047 (ALK2-IN-4) is an ALK2 inhibitor with potential anticancer activity and can be used in the study of non-small cell lung cancer. |
|
T76717 |
Serplulimab
|
HLX 10 |
COX
|
|
Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal squamous cell carcinoma. |
|
T6084 |
Rabusertib
|
LY2603618,IC-83 |
Chk
,
PDK
,
Autophagy
|
|
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance... |
|
T72043 |
SCFSkp2-IN-2
|
|
Apoptosis
,
E1/E2/E3 Enzyme
|
|
SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells. |
|
T76792 |
Sibrotuzumab
|
BIBH 1,Anti-Human FAP Recombinant Antibody |
Others
|
|
Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targeting Fibroblast Activating Protein (FAP).Sibrotuzumab is used in the study of colorectal cancer and non-small cell lung cancer. |
|
T26754 |
BC-23
|
NSC 45382,BC 23,BC23,NSC-45382,NSC45382 |
Proteasome
|
|
BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in the study of leukemias, lymphomas, gliomas, breast cancer, an... |
|
T14685 |
BMS-986158
|
|
Epigenetic Reader Domain
|
|
BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells. |
|
T9901A-002 |
Enoblituzumab
|
MGA271,TJ-271 |
Others
|
|
Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung cancer (NSCLC). |
|
T13564L2 |
AZ7550 trimesylate salt
|
AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base) |
MLK
|
|
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer. |
|
T83966 |
LSD1-IN-30
|
|
Histone Demethylase
|
|
LSD1-IN-30 is a lysine-specific demethylase 1 (LSD1) inhibitor with anticancer activity for the study of small cell lung cancer and acute myeloid leukemia. |
|
T78156 |
MC4033
|
|
Apoptosis
,
Histone Acetyltransferase
|
|
MC4033 is a selective lysine acetyltransferase 8 (KAT8) inhibitor (IC50: 12.1 μM) with anticancer effects, induces apoptosis, and can be used for the study of non-small cell lung cancer. |
|
T35901 |
EGFR-IN-99
|
JBJ-03-142-02 |
EGFR
,
HER
|
|
EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC). |
|
T40292 |
Opnurasib
|
NVP-JDQ443,JDQ-443,Opnurasib |
Ras
|
|
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell lung cancer. |
|
T9089 |
FTO-IN-1
|
UUN44923 |
Others
|
|
UUN44923 is a FTO inhibitor. It may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a h... |
|
T61016 |
EMI1
|
|
EGFR
|
|
EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1]. |
|
T9754 |
BLU-945
|
BLU945,BLU 945 |
EGFR
|
|
BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR with L858R and/or exon 19 deletion mutations, T790M, and C797... |
|
T35391 |
Vibostolimab (anti-TIGIT)
|
Vibostolimab (anti-TIGIT) |
Others
|
|
Vibostolimab is a monoclonal antibody against T cell immune proteins and the ITIM domain.Vibostolimab has shown anti-tumor activity in in vitro trials and can be used to study non-small cell lung cancer (NSCLC) and melan... |
|
T9460 |
IMDK
|
|
PI3K
|
|
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors withou... |
|
T60039 |
KSQ-4279
|
USP1-IN-1 |
PARP
,
DUB
|
|
KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ... |
|
T76796 |
Patritumab
|
U3-1287,AMG-888 |
ERK
,
EGFR
,
Akt
,
HER
|
|
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritumab promotes apoptosis and inhibits proliferation in non-sm... |
|
T36316 |
MTOR inhibitor-8
|
mTOR-IN-8 |
mTOR
,
Autophagy
|
|
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer. |
|
T35392 |
Tiragolumab
|
RO 7092284,RG6058-10,MTIG-7192A,RG6058-11,RG-6058 |
Others
|
|
Tiragolumab(MTIG-7192A) is a monoclonal antibody that targets T-cell immunoglobulin and the ITIM structural domain (TIGIT).Tiragolumab is often used in combination with the PD-L1 inhibitor, Atezolizumab, for the treatmen... |
|
T76698 |
Rovalpituzumab
|
|
Gamma-secretase
|
|
Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjugates (ADCs). Rovalpituzumab has anticancer activity and is ... |
|
T35394 |
Sintilimab (anti-PD-1)
|
IBI308,Sintilimab (anti-PD-1) |
PD-1/PD-L1
|
|
Sintilimab (IBI308) is a humanized IgG4 monoclonal antibody with significant anti-tumor activity that restores endogenous anti-tumor T-cell responses by binding to PD-1 and thereby blocking the interaction of PD-1 with i... |
|
T14997 |
Conteltinib
|
SY-707,CT-707 |
FAK
,
PYK2
,
ALK
|
|
Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hypoxia-mediated sorafenib resistance in hepatocellular carci... |
|
T72784 |
OTUB1/USP8-IN-1
|
|
DUB
|
|
OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung c... |
|
T2490 |
Osimertinib
|
AZD-9291,Mereletinib |
EGFR
|
|
Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irreversible and oral activity. Osimertinib has antitumor activi... |
|
T22443 |
Triglycidyl isocyanurate
|
Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI |
Apoptosis
|
|
Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk... |
